Galacardins A and B, new glycopeptide antibiotics.
نویسندگان
چکیده
A strain of actinomycetes identified as Saccharothrix sp. SANK 64289 was found to produce new antibiotics, galacardins A and B. Their physico-chemical properties showed that they were new members of glycopeptide antibiotics. They were structurally related to beta-avoparcin but differed from it only in sugar composition. Though beta-avoparcin does not contain galactose, galacardins A and B did contain two and one moles of galactose, respectively. They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus infection in mice.
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عنوان ژورنال:
- The Journal of antibiotics
دوره 45 3 شماره
صفحات -
تاریخ انتشار 1992